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It looked like a startle reflex—her arms rigid at her side, her face a frozen mask of fear, her eyes fluttering from side to side. From their small town in southwestern Maine, Meagan and her husband, Ken, took Addy to Boston to consult with neurologists. These epileptic seizures, they concluded, were the result of a congenital brain malformation called schizencephaly. She also had a related condition called optic nerve hypoplasia, which caused her eyes to wander—and which, further tests revealed, made her all but blind.

By summer Addy was having 20 to 30 seizures a day.

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Then a day. Then The powerful meds reduced her seizures, but they also put her to sleep for almost the entire day. Like a rag doll. Meagan quit her job as a third-grade teacher to care for her daughter. Over nine months Addy was hospitalized 20 times. But she did her own research. A good deal of anecdotal evidence shows that high-CBD strains of cannabis can have a strong antiseizure effect. The medical literature, though scant, goes back surprisingly far. Legally, Thiele could not prescribe cannabis to Addy or even recommend it.

But she strongly advised the Patricks to consider all medical options. What Meagan saw in Colorado impressed her—the growing knowledge base of cannabis producers, the kinship of parents coping with similar ordeals, the quality of the dispensaries, and the expertise of the test labs in ensuring consistent cannabis-oil formulations. Colorado Springs had become a mecca for a remarkable medical migration. More than a hundred families with children who had life-threatening medical conditions had uprooted themselves and moved.

Meagan experimented with high-CBD oil. The seizures all but stopped. By early last year the Patricks had made up their minds. They would move to Colorado to join the movement.

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Pikes Peak looms in their living room window. Addy is thriving. Her eyes wander less.

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She listens more. She laughs. Critics contend that the Realm of Caring parents are using their kids as guinea pigs, that not enough studies have been done, that many, if not most, of the claims can be dismissed as the result of the placebo effect. Without it, our Addy would be a sack of potatoes.

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  6. Thiele says early results of the CBD study are extremely encouraging. It clearly can be a very effective treatment for many people. And yet there are so many basic problems that need to be answered. Where did it come from?

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    How and why did it evolve? Why does it make all these suites of compounds? These plants, like nearly all hemp varieties, carry extremely low levels of THC. They may not look threatening, but their very presence here, in the confines of a major university lab, represents years of wrangling to win federal and university approval.

    Kane fingers one of his innocuous-looking plants, expressing mild bemusement at the U. There are places where farmers in the U. A geneticist, Kane studies cannabis from a unique perspective—he probes its DNA.

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    He has studied chocolate and for many years the sunflower, eventually mapping its genome, a sequence of more than three and a half billion nucleotides. Though its sequence is much shorter, roughly million nucleotides, he considers it a far more intriguing plant. You can feel it. People are just wanting this to happen. As Kane leads me around his lab, I see the excitement on his face and on the faces of his young staff. The place feels almost like a start-up company. It will be transformative. Transformative not just in our understanding of the plant but also of ourselves—our brains, our neurology, our psychology.

    Transformative in terms of the biochemistry of its compounds. With society pressuring many people to quit or to repeatedly attempt it, the withdrawal symptoms result in a lot of stress and anxiety for people, factors that may contribute to vulnerable persons developing symptoms of schizophrenia at an earlier age. As was posted earlier, according to the following U. National Institute of Mental Health website:.

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    I know there are spiritual ramifications and curses as well.. Genetics, heredity and alcohol are THEE only things on record that are believed to cause psychosis and schizophrenia. The science community has long known schizophrenia runs in the family. The chemistry and structure changes in the brain, if any, caused by marijuana, are as much an argument against your claims as it is an argument for them.

    Your claims, not facts, in my opinion, are mostly based on your anti-marijuana views and the fact your university is heavily involved and invested with the pharmaceutical industries. I agree.

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    These sound like a bunch of propaganda studies funded by the DEA. We know that medical marijuana studies were stopped under The Ford Administration in They banned independent research and research by federal health programs on the use of natural cannabis derivatives for medicine for years. In researchers at the Medical College of Virginia, funded by the National Institute of Health to find evidence that marijuana damages the immune system, found instead that THC slowed the growth of three kinds of cancer in mice — lung and breast cancer, and a virus-induced leukemia.

    Lets also keep in mind that marijuana is a natural plant not an illicit drug. Tobacco and marijuana are two very different things, and for most of the population, marijuana IS NOT an addictive substance. Alarming and eye-opener excellent article. It is very important for teenagers and adults to know the consequences of using marijuana.

    There are still many side effects to discover but the ones we already know are shocking and not worth the risk at all. If only more people were made aware of the dangers…there would be less traumatised families and young people being kept on lithium in asylums. In the concept of integrative oncology, the healthcare provider may recommend medicinal Cannabis not just for symptom management but in addition for its likely direct antitumor effect. Because cannabinoid receptors can be found in tissue through the body, not only within the nervous system, negative effects include tachycardia, hypotension, conjunctival injection, bronchodilation, muscle relaxation, and decreased intestinal motility.

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    Although cannabinoids are thought by some to become addictive drugs, their addictive potential is substantially lower compared to other recommended agents or substances of abuse. I wonder what the mindless furor of fear factor, joe rogan, would say if presented with this study. That numbskull is one of the biggest proponents of legalize marijuana this side of a rock. As a point of fact I feel a need to mention that marijuana is by far one the least harmful substances being consumed today on a recreational basis as The most commonly used painkiller in the US is acetaminophen brand name Tylenol. This is easily available over the counter. Acetaminophen is also in sleep aids for instance, Tylenol-PM , and in strong prescription narcotic painkillers such as Vicodin and Percocet. Recent studies have found that acetaminophen is the leading cause of liver damage and probably is responsible for cases of acute liver failure that occur each year.

    The drug is thought to be safe at the recommended dose but because it is in so many different kinds of medication, people often end up taking double or even triple doses if they are using different painkillers or sleep aids. In , the Journal of the American Medical Association published a study that stated that prescription medications were the fourth leading cause of death in America. Another study reported that there were , deaths per year from non-error, adverse effects of medications.

    And are you ready for the really scary part of this as if that was not enough — 2. Not from accidental or intentional overdose, just from taking the prescribed dose. Here is another scary fact: more than half of the experts hired to advise our government on the safety and efficacy of prescription medications have a financial interest or relationship with the pharmaceutical companies that will benefit by their decisions. Here is some information from an article by Peter Breggin in Psychology Today in July hope you are sitting down because this is almost unbelievable :.

    While it may take a decade for a drug to get through the FDA bureaucracy, the actual controlled scientific studies last—as in the case of Prozac—just four to six weeks. For starters, seriously suicidal patients and hospitalized patients were excluded.

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    After weeding out the most badly flawed studies, the FDA found only four that were adequate enough to consider. One of these showed that Prozac was no better than placebo. Three others supposedly showed Prozac to be somewhat superior to the sugar pill, but not as good as older antidepressants. However, due to adverse drug effects and lack of drug effectiveness, the dropout rates in most of these studies was very high. While the gross number of patients receiving Prozac in all the trials was more than 5,, the actual number finishing the trials used for approval was very small.

    When I counted the actual number of patients who completed the four- to six-week trials used for the approval of Prozac, it turned out to be a grand total of Because of the high dropout rates and because Prozac was often no better than placebo in many trials, many statistical maneuvers were required to make the studies look positive.

    In one of the key studies, involving six different sites around the country, results at five sites showed Prozac to have no benefit. One site—representing 25 percent of the patients who finished the trials—was discarded. Then the data from the remaining sites were pooled.